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Literature summary for 5.3.1.9 extracted from

  • Abbas, S.; Mok, K.; Rashid, N.; Xie, Y.; Ruether, M.; OBrien, J.; Akhtar, M.
    NMR studies on mechanism of isomerisation of fructose 6-phosphate to glucose 6-phosphate catalysed by phosphoglucose isomerase from Thermococcus kodakarensis (2016), Bioorg. Chem., 66, 41-45 .
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ meta-dependent phosphoglucose isomerase which requires Zn2+ for its activity. The presence of metal electrophile to activate the carbonyl group is required not only for the hydride shift mechanism but also for the operation of an enediol process Thermococcus kodakarensis
Zn2+ the presence of a metal electrophile to activate the carbonyl group is required not only for the hydride shift mechanism but also for the operation of an enediol process Thermococcus kodakarensis

Organism

Organism UniProt Comment Textmining
Thermococcus kodakarensis
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Thermococcus kodakarensis Q5JE38
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 6-phosphate
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Thermococcus kodakarensis D-glucose 6-phosphate
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?
D-fructose 6-phosphate the isomerization occurrs by a cis-enediol intermediate involving C-1 pro-R hydrogen of D-fructose 6-phosphate. The presence of metal electrophile to activate the carbonyl group is required not only for the hydride shift mechanism but also for the operation of an enediol process Thermococcus kodakarensis D-glucose 6-phosphate
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r
additional information the isomerization occurs by a cis-enediol intermediate involving the C-1 pro-R hydrogen atom of fructose 6-phosphate. The presence of a metal electrophile to activate the carbonyl group is required not only for the hydride shift mechanism but also for the operation of an enediol process Thermococcus kodakarensis ?
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?

Synonyms

Synonyms Comment Organism
PGI
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Thermococcus kodakarensis
Phosphoglucose isomerase
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Thermococcus kodakarensis
TK1111 locus name Thermococcus kodakarensis