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Literature summary for 5.3.1.8 extracted from

  • Nic Lochlainn, L.; Caffrey, P.
    Phosphomannose isomerase and phosphomannomutase gene disruptions in Streptomyces nodosus: impact on amphotericin biosynthesis and implications for glycosylation engineering (2009), Metab. Eng., 11, 40-47.
    View publication on PubMed

Application

Application Comment Organism
synthesis inactivation of the manA gene encoding phosphomannose isomerase results in production of amphotericins and their aglycones, 8-deoxyamphoteronolides. A double mutant lacking the phosphomannose isomerase and phosphomannomutase genes produces 8-deoxyamphoteronolides in good yields along with trace levels of glycosylated amphotericins Streptomyces nodosus

Cloned(Commentary)

Cloned (Comment) Organism
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Streptomyces nodosus

Protein Variants

Protein Variants Comment Organism
additional information inactivation of the manA gene encoding phosphomannose isomerase results in production of amphotericins and their aglycones, 8-deoxyamphoteronolides. A double mutant lacking the phosphomannose isomerase and phosphomannomutase genes produces 8-deoxyamphoteronolides in good yields along with trace levels of glycosylated amphotericins Streptomyces nodosus

Organism

Organism UniProt Comment Textmining
Streptomyces nodosus
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