Literature summary for 5.3.1.8 extracted from

Wells, T.N.C.; Payton, M.A.; Proudfoot, A.E.I.
Inhibition of phosphomannose isomerase by mercury ions (1994), Biochemistry, 33, 7641-7646.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Hg2+	partial noncompetitive inhibition with mannose 6-phosphate as substrate. In addition to the inhibition at rapid equilibrium, inactivation occurs in a two-step process, proceeding via an intermediate complex. The rate of the irreversible inactivation can be slowed by the addition of the substrate mannose 6-phosphate	Candida albicans
Hg2+	-	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-
Homo sapiens	-	-	-
Saccharomyces cerevisiae	-	-	-
Sus scrofa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Mannose 6-phosphate	-	Homo sapiens	D-Fructose 6-phosphate	-	?
D-Mannose 6-phosphate	-	Sus scrofa	D-Fructose 6-phosphate	-	?
D-Mannose 6-phosphate	-	Saccharomyces cerevisiae	D-Fructose 6-phosphate	-	?
D-Mannose 6-phosphate	-	Candida albicans	D-Fructose 6-phosphate	-	?

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Release 2023.1 (January 2023)