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Literature summary for 5.3.1.4 extracted from
- Current studies on biological tagatose production using L-arabinose isomerase: a review and future perspective (2004), Appl. Microbiol. Biotechnol., 65, 243-249.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | additionally, D-tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Geobacillus stearothermophilus |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Klebsiella aerogenes |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Lactobacillus gayonii |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Thermotoga neapolitana |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Thermus sp. |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Vibrio parahaemolyticus |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Yersinia pestis |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Shigella flexneri |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Bacillus subtilis |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Halalkalibacterium halodurans |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Oceanobacillus iheyensis |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Lactiplantibacillus plantarum |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Clostridium acetobutylicum |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Bifidobacterium longum |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Bacteroides thetaiotaomicron |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Escherichia coli |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Thermoanaerobacter mathranii |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Thermotoga maritima |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Salmonella enterica subsp. enterica serovar Typhi |
| additional information | additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick | Salmonella enterica subsp. enterica serovar Typhimurium |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Geobacillus stearothermophilus |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Klebsiella aerogenes |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Lactobacillus gayonii |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Thermotoga neapolitana |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Thermus sp. |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Vibrio parahaemolyticus |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Yersinia pestis |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Shigella flexneri |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Bacillus subtilis |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Halalkalibacterium halodurans |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Oceanobacillus iheyensis |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Lactiplantibacillus plantarum |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Clostridium acetobutylicum |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Bifidobacterium longum |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Bacteroides thetaiotaomicron |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Escherichia coli |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Thermoanaerobacter mathranii |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Thermotoga maritima |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Salmonella enterica subsp. enterica serovar Typhi |
| nutrition | there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener | Salmonella enterica subsp. enterica serovar Typhimurium |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Vibrio parahaemolyticus |
- |
Yersinia pestis |
- |
Shigella flexneri |
- |
Bacillus subtilis |
- |
Halalkalibacterium halodurans |
- |
Oceanobacillus iheyensis |
- |
Lactiplantibacillus plantarum |
- |
Clostridium acetobutylicum |
- |
Bifidobacterium longum |
- |
Bacteroides thetaiotaomicron |
- |
Thermotoga maritima |
- |
Salmonella enterica subsp. enterica serovar Typhi |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
| expression in Escherichia coli | Escherichia coli |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | five point mutations increase the activity 11fold in the first round of evolution, and three point mutations in the second round of evolution increase the activity 5fold beyond the activity from the first round | Geobacillus stearothermophilus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | serves as catalyst | Geobacillus stearothermophilus |  |
| Ca2+ | serves as catalyst | Klebsiella aerogenes | |
| Ca2+ | serves as catalyst | Lactobacillus gayonii | |
| Ca2+ | serves as catalyst | Thermotoga neapolitana | |
| Ca2+ | serves as catalyst | Thermus sp. | |
| Ca2+ | serves as catalyst | Vibrio parahaemolyticus | |
| Ca2+ | serves as catalyst | Yersinia pestis | |
| Ca2+ | serves as catalyst | Shigella flexneri | |
| Ca2+ | serves as catalyst | Bacillus subtilis | |
| Ca2+ | serves as catalyst | Halalkalibacterium halodurans | |
| Ca2+ | serves as catalyst | Oceanobacillus iheyensis | |
| Ca2+ | serves as catalyst | Lactiplantibacillus plantarum | |
| Ca2+ | serves as catalyst | Clostridium acetobutylicum | |
| Ca2+ | serves as catalyst | Bifidobacterium longum | |
| Ca2+ | serves as catalyst | Bacteroides thetaiotaomicron | |
| Ca2+ | serves as catalyst | Escherichia coli | |
| Ca2+ | serves as catalyst | Thermoanaerobacter mathranii | |
| Ca2+ | serves as catalyst | Thermotoga maritima | |
| Ca2+ | serves as catalyst | Salmonella enterica subsp. enterica serovar Typhi | |
| Ca2+ | serves as catalyst | Salmonella enterica subsp. enterica serovar Typhimurium | |
| Mn2+ | activates the enzyme | Klebsiella aerogenes | |
| Mn2+ | activates the enzyme | Lactobacillus gayonii | |
| Mn2+ | activates the enzyme | Escherichia coli | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
- |
Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-galactose | Geobacillus stearothermophilus | - |
D-tagatose | - |
? | |
| D-galactose | Klebsiella aerogenes | - |
D-tagatose | - |
? | |
| D-galactose | Lactobacillus gayonii | - |
D-tagatose | - |
? | |
| D-galactose | Thermotoga neapolitana | - |
D-tagatose | - |
? | |
| D-galactose | Thermus sp. | - |
D-tagatose | - |
? | |
| D-galactose | Vibrio parahaemolyticus | - |
D-tagatose | - |
? | |
| D-galactose | Yersinia pestis | - |
D-tagatose | - |
? | |
| D-galactose | Shigella flexneri | - |
D-tagatose | - |
? | |
| D-galactose | Bacillus subtilis | - |
D-tagatose | - |
? | |
| D-galactose | Halalkalibacterium halodurans | - |
D-tagatose | - |
? | |
| D-galactose | Oceanobacillus iheyensis | - |
D-tagatose | - |
? | |
| D-galactose | Lactiplantibacillus plantarum | - |
D-tagatose | - |
? | |
| D-galactose | Clostridium acetobutylicum | - |
D-tagatose | - |
? | |
| D-galactose | Bifidobacterium longum | - |
D-tagatose | - |
? | |
| D-galactose | Bacteroides thetaiotaomicron | - |
D-tagatose | - |
? | |
| D-galactose | Escherichia coli | - |
D-tagatose | - |
? | |
| D-galactose | Thermoanaerobacter mathranii | - |
D-tagatose | - |
? | |
| D-galactose | Thermotoga maritima | - |
D-tagatose | - |
? | |
| D-galactose | Salmonella enterica subsp. enterica serovar Typhi | - |
D-tagatose | - |
? | |
| D-galactose | Salmonella enterica subsp. enterica serovar Typhimurium | - |
D-tagatose | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | P94523 | - |
- |
| Bacteroides thetaiotaomicron | Q8AAW1 | - |
- |
| Bifidobacterium longum | Q8G7J3 | - |
- |
| Clostridium acetobutylicum | Q97JE0 | - |
- |
| Clostridium acetobutylicum | Q97JE4 | - |
- |
| Escherichia coli | P08202 | - |
- |
| Escherichia coli | P58538 | - |
- |
| Escherichia coli | Q8FL89 | - |
- |
| Geobacillus stearothermophilus | - |
- |
- |
| Halalkalibacterium halodurans | Q9KBQ2 | - |
- |
| Klebsiella aerogenes | - |
- |
- |
| Lactiplantibacillus plantarum | Q88S84 | - |
- |
| Lactobacillus gayonii | - |
- |
- |
| Oceanobacillus iheyensis | Q8EMP4 | - |
- |
| Salmonella enterica subsp. enterica serovar Typhi | P58539 | - |
- |
| Salmonella enterica subsp. enterica serovar Typhimurium | P06189 | - |
- |
| Shigella flexneri | Q7UDT4 | - |
- |
| Thermoanaerobacter mathranii | - |
- |
- |
| Thermotoga maritima | Q9WYB3 | - |
- |
| Thermotoga neapolitana | - |
- |
- |
| Thermus sp. | - |
- |
- |
| Vibrio parahaemolyticus | - |
- |
- |
| Yersinia pestis | P58540 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-galactose | - |
Geobacillus stearothermophilus | D-tagatose | - |
? | |
| D-galactose | - |
Klebsiella aerogenes | D-tagatose | - |
? | |
| D-galactose | - |
Lactobacillus gayonii | D-tagatose | - |
? | |
| D-galactose | - |
Thermotoga neapolitana | D-tagatose | - |
? | |
| D-galactose | - |
Thermus sp. | D-tagatose | - |
? | |
| D-galactose | - |
Vibrio parahaemolyticus | D-tagatose | - |
? | |
| D-galactose | - |
Yersinia pestis | D-tagatose | - |
? | |
| D-galactose | - |
Shigella flexneri | D-tagatose | - |
? | |
| D-galactose | - |
Bacillus subtilis | D-tagatose | - |
? | |
| D-galactose | - |
Halalkalibacterium halodurans | D-tagatose | - |
? | |
| D-galactose | - |
Oceanobacillus iheyensis | D-tagatose | - |
? | |
| D-galactose | - |
Lactiplantibacillus plantarum | D-tagatose | - |
? | |
| D-galactose | - |
Clostridium acetobutylicum | D-tagatose | - |
? | |
| D-galactose | - |
Bifidobacterium longum | D-tagatose | - |
? | |
| D-galactose | - |
Bacteroides thetaiotaomicron | D-tagatose | - |
? | |
| D-galactose | - |
Escherichia coli | D-tagatose | - |
? | |
| D-galactose | - |
Thermoanaerobacter mathranii | D-tagatose | - |
? | |
| D-galactose | - |
Thermotoga maritima | D-tagatose | - |
? | |
| D-galactose | - |
Salmonella enterica subsp. enterica serovar Typhi | D-tagatose | - |
? | |
| D-galactose | - |
Salmonella enterica subsp. enterica serovar Typhimurium | D-tagatose | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | alpha6 | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AI | - |
Geobacillus stearothermophilus |
| AI | - |
Klebsiella aerogenes |
| AI | - |
Lactobacillus gayonii |
| AI | - |
Thermotoga neapolitana |
| AI | - |
Thermus sp. |
| AI | - |
Vibrio parahaemolyticus |
| AI | - |
Yersinia pestis |
| AI | - |
Shigella flexneri |
| AI | - |
Bacillus subtilis |
| AI | - |
Halalkalibacterium halodurans |
| AI | - |
Oceanobacillus iheyensis |
| AI | - |
Lactiplantibacillus plantarum |
| AI | - |
Clostridium acetobutylicum |
| AI | - |
Bifidobacterium longum |
| AI | - |
Bacteroides thetaiotaomicron |
| AI | - |
Escherichia coli |
| AI | - |
Thermoanaerobacter mathranii |
| AI | - |
Thermotoga maritima |
| AI | - |
Salmonella enterica subsp. enterica serovar Typhi |
| AI | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| L-arabinose isomerase | - |
Geobacillus stearothermophilus |
| L-arabinose isomerase | - |
Klebsiella aerogenes |
| L-arabinose isomerase | - |
Lactobacillus gayonii |
| L-arabinose isomerase | - |
Thermotoga neapolitana |
| L-arabinose isomerase | - |
Thermus sp. |
| L-arabinose isomerase | - |
Vibrio parahaemolyticus |
| L-arabinose isomerase | - |
Yersinia pestis |
| L-arabinose isomerase | - |
Shigella flexneri |
| L-arabinose isomerase | - |
Bacillus subtilis |
| L-arabinose isomerase | - |
Halalkalibacterium halodurans |
| L-arabinose isomerase | - |
Oceanobacillus iheyensis |
| L-arabinose isomerase | - |
Lactiplantibacillus plantarum |
| L-arabinose isomerase | - |
Bifidobacterium longum |
| L-arabinose isomerase | - |
Bacteroides thetaiotaomicron |
| L-arabinose isomerase | - |
Escherichia coli |
| L-arabinose isomerase | - |
Thermoanaerobacter mathranii |
| L-arabinose isomerase | - |
Thermotoga maritima |
| L-arabinose isomerase | - |
Salmonella enterica subsp. enterica serovar Typhi |
| L-arabinose isomerase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| L-arabinose isomerase 1 | - |
Clostridium acetobutylicum |
| L-arabinose isomerase 2 | - |
Clostridium acetobutylicum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | - |
Geobacillus stearothermophilus |
| 7.5 | 8.5 | - |
Klebsiella aerogenes |
| 7.5 | 8.5 | - |
Lactobacillus gayonii |
| 7.5 | 8.5 | - |
Thermotoga neapolitana |
| 7.5 | 8.5 | - |
Thermus sp. |
| 7.5 | 8.5 | - |
Vibrio parahaemolyticus |
| 7.5 | 8.5 | - |
Yersinia pestis |
| 7.5 | 8.5 | - |
Shigella flexneri |
| 7.5 | 8.5 | - |
Bacillus subtilis |
| 7.5 | 8.5 | - |
Halalkalibacterium halodurans |
| 7.5 | 8.5 | - |
Oceanobacillus iheyensis |
| 7.5 | 8.5 | - |
Lactiplantibacillus plantarum |
| 7.5 | 8.5 | - |
Clostridium acetobutylicum |
| 7.5 | 8.5 | - |
Bifidobacterium longum |
| 7.5 | 8.5 | - |
Bacteroides thetaiotaomicron |
| 7.5 | 8.5 | - |
Escherichia coli |
| 7.5 | 8.5 | - |
Thermoanaerobacter mathranii |
| 7.5 | 8.5 | - |
Thermotoga maritima |
| 7.5 | 8.5 | - |
Salmonella enterica subsp. enterica serovar Typhi |
| 7.5 | 8.5 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | - |
Clostridium acetobutylicum |
| 7.5 | 8.5 | - |
Escherichia coli |
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