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Literature summary for 5.3.1.24 extracted from

  • Adams, N.E; Thiaville, J.J; Proestos, J.; Juarez-Vazquez, A.L.; McCoy, A.J.; Barona-Gomez, F.; Iwata-Reuyl, D.; de Crecy-Lagard, V.; Maurelli, A.T.
    Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species (2014), mBio, 5, e01378-14.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.1.24

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Chlamydia trachomatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one Chlamydia trachomatis
-
 7,8-dihydroneopterin 3'-phosphate + H2O
-
 ?
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one Chlamydia trachomatis ATCC VR-902B
-
 7,8-dihydroneopterin 3'-phosphate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Chlamydia trachomatis B0B7P4 bifunctional enzyme, additionally catalyes the reaction of EC 4.2.1.160
-
Chlamydia trachomatis ATCC VR-902B B0B7P4 bifunctional enzyme, additionally catalyes the reaction of EC 4.2.1.160
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
-
 Chlamydia trachomatis 7,8-dihydroneopterin 3'-phosphate + H2O
-
 ?
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
-
 Chlamydia trachomatis ATCC VR-902B 7,8-dihydroneopterin 3'-phosphate + H2O
-
 ?
additional information besides phosphoribosyl anthranilate isomerase activity, enzyme is involved in folate synthesis, reaction of EC 4.2.1.160 Chlamydia trachomatis ?
-
 ?
additional information besides phosphoribosyl anthranilate isomerase activity, enzyme is involved in folate synthesis, reaction of EC 4.2.1.160 Chlamydia trachomatis ATCC VR-902B ?
-
 ?

Synonyms

Synonyms Comment Organism
N-(5'-phosphoribosyl)anthranilate isomerase/dehydratase
-
 Chlamydia trachomatis
TrpFCtL2
-
 Chlamydia trachomatis

General Information

General Information Comment Organism
physiological function enzyme TrpFCtL2, in combination with GTP cyclohydrolase II, i.e. RibA, the first enzyme of riboflavin synthesis, provides a bypass of the first two canonical steps in folate synthesis catalyzed by FolE and FolQ. TrpFCtL2 retains the phosphoribosyl anthranilate isomerase activity of the original annotation Chlamydia trachomatis