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Literature summary for 5.3.1.24 extracted from

  • Priestle, J.P.; Gruetter, M.G.; White, J.L.; Vincent, M.G.; Kania, M; Wilson, E.; Jardetzky, T.S.; Kirschner, K.; Jansonius, J.N.
    Three-dimensional structure of the bifunctional enzyme N-(5'-phosphoribosyl)anthranilate isomerase-indole-3-glycerol-phosphate synthase from Escherichia coli (1987), Proc. Natl. Acad. Sci. USA, 84, 5690-5694.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
sequence of trpCF gene encoding indole-3-glycerol-phosphate synthetase/PRA isomerase complex Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
three-dimensional structure of indole-3-glycerol-phosphate synthetase/PRA isomerase complex determined by X-ray crystallography Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
reduced 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-(5-phospho-beta-D-ribosyl)anthranilate Escherichia coli involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 bifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(5-phospho-beta-D-ribosyl)anthranilate structure of the indole-3-glycerol-phosphate synthetase/PRA isomerase complex, 2 well-defined functional domains: N-terminal indole-3-glycerol-phosphate synthetase, residues 1-255, and C-terminal PRA isomerase, residues 256-452, with limited noncovalent contacts between the domains, the two reactions are catalyzed independently from each other Escherichia coli 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Escherichia coli 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Escherichia coli