Literature summary for 5.3.1.21 extracted from

  • Monder, C.M; Marandici, A.
    Corticosteroid side-chain isomerase in the circulatory system (1991), Steroids, 56, 12-16.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Co2+
-
Canis lupus familiaris
Co2+
-
Oryctolagus cuniculus
Co2+
-
Ovis aries
Ni2+
-
Canis lupus familiaris
Ni2+
-
Oryctolagus cuniculus
Ni2+
-
Ovis aries

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ no effect Sus scrofa
Co2+ no effect Bos taurus
Co2+ no effect Equus caballus
Ni2+ no effect Sus scrofa
Ni2+ no effect Bos taurus
Ni2+ no effect Equus caballus
Co2+ stimulates Gallus gallus
Co2+ stimulates Cavia porcellus
Co2+ stimulates Mus musculus
Co2+ stimulates Rattus norvegicus
Ni2+ stimulates Gallus gallus
Ni2+ stimulates Cavia porcellus
Ni2+ stimulates Mus musculus
Ni2+ stimulates Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
cow
-
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-
Gallus gallus
-
-
-
Oryctolagus cuniculus
-
-
-
Equus caballus
-
-
-
Ovis aries
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Gallus gallus
-
blood
-
Cavia porcellus
-
blood
-
Homo sapiens
-
blood
-
Rattus norvegicus
-
blood
-
Sus scrofa
-
blood
-
Bos taurus
-
blood
-
Ovis aries
-
blood
-
Equus caballus
-
blood erythrocytes show the highest activity, plasma low, and white blood cells low but highly variable levels of enzyme, circulating isomerase is derived in part from tissue sources and is in part an intrinsic blood enzyme Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-Deoxycorticosterone
-
Gallus gallus 20-Hydroxy-3-oxopregn-4-en-21-al
-
?
11-Deoxycorticosterone
-
Cavia porcellus 20-Hydroxy-3-oxopregn-4-en-21-al
-
?
11-Deoxycorticosterone
-
Mus musculus 20-Hydroxy-3-oxopregn-4-en-21-al
-
?
11-Deoxycorticosterone
-
Homo sapiens 20-Hydroxy-3-oxopregn-4-en-21-al
-
?
11-Deoxycorticosterone
-
Rattus norvegicus 20-Hydroxy-3-oxopregn-4-en-21-al
-
?
11-Deoxycorticosterone
-
Sus scrofa 20-Hydroxy-3-oxopregn-4-en-21-al
-
?
11-Deoxycorticosterone
-
Bos taurus 20-Hydroxy-3-oxopregn-4-en-21-al
-
?
11-Deoxycorticosterone
-
Oryctolagus cuniculus 20-Hydroxy-3-oxopregn-4-en-21-al
-
?
11-Deoxycorticosterone
-
Ovis aries 20-Hydroxy-3-oxopregn-4-en-21-al
-
?
11-Deoxycorticosterone
-
Canis lupus familiaris 20-Hydroxy-3-oxopregn-4-en-21-al
-
?
11-Deoxycorticosterone
-
Equus caballus 20-Hydroxy-3-oxopregn-4-en-21-al
-
?