Literature summary for 5.3.1.1 extracted from

Wang, X.; Lu, Y.; Yang, J.; Shi, Y.; Lan, M.; Liu, Z.; Zhai, H.; Fan, D.
Identification of triosephosphate isomerase as an anti-drug resistance agent in human gastric cancer cells using functional proteomic analysis (2008), J. Cancer Res. Clin. Oncol., 134, 995-1003.

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Application

Application	Comment	Organism
medicine	in drug-resistant SGC7901 cells induced by vincristine sulfate, triosephosphate isomerase is downregulated.The sensitivity of TPI-SGC7901/VCR cells to adriamycin, vincristine, 5-fluorouracil and cis-dichlorodiamine platinum, as well as the accumulation and retention to adriamycin, are significantly increased when compared to their control cell lines	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	in drug-resistant SGC7901 cells induced by vincristine sulfate, triosephosphate isomerase is downregulated.The sensitivity of TPI-SGC7901/VCR cells to adriamycin, vincristine, 5-fluorouracil and cis-dichlorodiamine platinum, as well as the accumulation and retention to adriamycin, are significantly increased when compared to their control cell lines	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SGC-7901 cell	gastric cancer cell	Homo sapiens	-

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Release 2023.1 (January 2023)