Application | Comment | Organism |
---|---|---|
medicine | PIN1 inhibition dramatically reduces the tumor volume in a subcutaneous mouse xenograft model and angiogenesis as well as hypoxia-induced transcriptional activity of hypoxia-inducible factor HIF-1alpha | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13526 | - |
- |
Mus musculus | Q9QUR7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Pin1 | - |
Homo sapiens |
Pin1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | PIN1 directly interacts with hypoxia-inducible factor HIF-1alpha in human colon cancer cells. PIN1 binding occurs in a phosphorylation-dependent manner, and at both exogenous and endogenous levels. Binding stabilizes the HIF-1alpha protein, resulting in increased transcriptional activity, and upregulating expression of vascular endothelial growth factor. Silencing of PIN1 or pharmacologic inhibition of its activity abrogates the angiogenesis | Homo sapiens |
physiological function | PIN1 inhibition dramatically reduces the tumor volume in a subcutaneous mouse xenograft model and angiogenesis as well as hypoxia-induced transcriptional activity of hypoxia-inducible factor HIF-1alpha | Mus musculus |