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Literature summary for 5.2.1.8 extracted from

  • Hidaka, M.; Kosaka, K.; Tsushima, S.; Uchida, C.; Takahashi, K.; Takahashi, N.; Tsubuki, M.; Hara, Y.; Uchida, T.
    Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1 (2018), Biochem. Biophys. Res. Commun., 499, 681-687 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(E)-6-phenylhexyl 3-(3,4-dihydroxyphenyl)acrylate 20 micorM, 15% residual activity Homo sapiens
epigallocatechin-3-gallate 10 microM, 55% residual activity Homo sapiens
additional information food polyphenols carrying a galloyl group show significant inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13526
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-Ala-Glu-(cis)-Pro-Phe-p-nitroanilide
-
Homo sapiens N-succinyl-Ala-Glu-(trans)-Pro-Phe-p-nitroanilide
-
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