Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | P54353 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(cis)-Pro residue in phosphorylated protein PERIOD | phosphorylated isoforms of PERIOD serve as Dod substrates, leading to Dod-mediated conformational changes of PERIOD | Drosophila melanogaster | (trans)-Pro residue in phosphorylated protein PERIOD | - |
r |
Synonyms | Comment | Organism |
---|---|---|
Dod | - |
Drosophila melanogaster |
Pin1 | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression lengthens the locomotor behavioral period. Dod associates preferentially with phosphorylated species of PERIOD, associated with the circadian clock machinery, which delays the phosphorylation-dependent degradation of PERIOD. PERIOD protein levels are higher in flies overexpressing Dod | Drosophila melanogaster |