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Literature summary for 5.2.1.8 extracted from

  • Kang, S.W.; Lee, E.; Cho, E.; Seo, J.H.; Ko, H.W.; Kim, E.Y.
    Drosophila peptidyl-prolyl isomerase Pin1 modulates circadian rhythms via regulating levels of PERIOD (2015), Biochem. Biophys. Res. Commun., 463, 235-240 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster P54353
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(cis)-Pro residue in phosphorylated protein PERIOD phosphorylated isoforms of PERIOD serve as Dod substrates, leading to Dod-mediated conformational changes of PERIOD Drosophila melanogaster (trans)-Pro residue in phosphorylated protein PERIOD
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r

Synonyms

Synonyms Comment Organism
Dod
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Drosophila melanogaster
Pin1
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Drosophila melanogaster

General Information

General Information Comment Organism
physiological function overexpression lengthens the locomotor behavioral period. Dod associates preferentially with phosphorylated species of PERIOD, associated with the circadian clock machinery, which delays the phosphorylation-dependent degradation of PERIOD. PERIOD protein levels are higher in flies overexpressing Dod Drosophila melanogaster