Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.2.1.8 extracted from

  • Bissoli, G.; Ninoles, R.; Fresquet, S.; Palombieri, S.; Bueso, E.; Rubio, L.; Garcia-Sanchez, M.J.; Fernandez, J.A.; Mulet, J.M.; Serrano, R.
    Peptidyl-prolyl cis-trans isomerase ROF2 modulates intracellular pH homeostasis in Arabidopsis (2012), Plant J., 70, 704-716.
    View publication on PubMed
Search for more literature for 5.2.1.8

Cloned(Commentary)

Cloned (Comment) Organism
gene ROF2, overexpression in transgenic Arabidopsis thaliana lines Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information overexpression of ROF2 confers tolerance to intracellular acidification by increasing proton extrusion from cells. Expression of ROF2 activates K+ uptake, causing depolarization of the plasma membrane, which activates the electrogenic plasma membrane proton pump, H+-ATPase Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
FK506
-
 Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
intracellular
-
 Arabidopsis thaliana 5622
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9FJL3 gene ROF2
-

Synonyms

Synonyms Comment Organism
Peptidyl-prolyl cis-trans isomerase
-
 Arabidopsis thaliana
ROF2
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana intracellular acid stress generated by weak organic acids at normal external pH induces expression of several chaperone genes, including ROF2 up

General Information

General Information Comment Organism
evolution ROF2 encodes a peptidyl-prolyl cis-trans isomerase of the FK506-binding protein class Arabidopsis thaliana
malfunction loss of function of ROF2, and especially double mutation of ROF2 and the closely related gene ROF1, results in acid sensitivity, stress and development phenotypes of ROF mutants, overview Arabidopsis thaliana
additional information ROF2 overexpressing plants show tolerance to toxic cations such as lithium, norspermidine and hygromycin B, whose uptake is driven by the membrane potential, due to activation of the electrogenic plasma membrane proton pump, ROF2 activates K+ transport, H+-ATPase, phenotypes, overview Arabidopsis thaliana
physiological function peptidyl-prolyl cis-trans isomerase ROF2 modulates intracellular pH homeostasis. As ROF2 induction and intracellular acidification are common consequences of many stresses, this mechanism of pH homeostasis may be of general importance for stress tolerance. Chaperone ROF2 not only helps to refold proteins but also activates H+ extrusion to restore intracellular pH Arabidopsis thaliana