Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C113A | isomerase-inactive | Homo sapiens |
S16A | isomerase-inactive | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
juglone | i.e. 5-hydroxy-1,4-naphthoquinone, natural inhibitor of Pin1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Peptidyl-prolyl cis-trans isomerase | - |
Homo sapiens |
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | - |
Homo sapiens |
Pin1 | - |
Homo sapiens |
PPIase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Pin1 expression is increased by NS5B protein | up |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing of Pin1 expression results in decrease of hepatitis C virus replication in both hepatitis C virus replicon cells and cell culture grown hepatitis C virus-infected cells | Homo sapiens |
physiological function | Pin1 is a host factor for hepatitis C virus propagation and may contribute to hepatitis C virus-induced liver pathogenesis. Both binding and isomerase activities of Pin1 are essential for hepatitis C virus replication | Homo sapiens |