Protein Variants | Comment | Organism |
---|---|---|
additional information | repression of Pin1 expression through either homologue Pin1 knockout or small interfering RNA-mediated knockdown compromises its ability to protect Akt from degradation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
serine/threonine protein kinase B | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 and the Thr92-Pro and Thr450-Pro motifs in multiple cancer types, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
serine/threonine protein kinase B | - |
Homo sapiens | ? | - |
? | |
serine/threonine protein kinase B | i.e. Akt, reduced activity with Akt mutants T92A/T450A and T92D/T450D. Akt-Pin1 interaction analysis using HA-tagged Akt and GST-tagged Pin1, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peptidyl-prolyl cis/trans isomerase | - |
Homo sapiens |
Pin1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Pin1 is critical for the regulation of serine/threonine protein kinase B, PKB/Akt, stability and activation phosphorylation at S473 through the phosphorylated Thr-Pro motifs of Akt. Roles of Akt and Pin1 in oncogenesis, overview | Homo sapiens |