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Literature summary for 5.2.1.8 extracted from

  • Liao, Y.; Wei, Y.; Zhou, X.; Yang, J.Y.; Dai, C.; Chen, Y.J.; Agarwal, N.K.; Sarbassov, D.; Shi, D.; Yu, D.; Hung, M.C.
    Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation (2009), Oncogene, 28, 2436-2445.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information repression of Pin1 expression through either homologue Pin1 knockout or small interfering RNA-mediated knockdown compromises its ability to protect Akt from degradation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
serine/threonine protein kinase B Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 and the Thr92-Pro and Thr450-Pro motifs in multiple cancer types, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
serine/threonine protein kinase B
-
Homo sapiens ?
-
?
serine/threonine protein kinase B i.e. Akt, reduced activity with Akt mutants T92A/T450A and T92D/T450D. Akt-Pin1 interaction analysis using HA-tagged Akt and GST-tagged Pin1, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
peptidyl-prolyl cis/trans isomerase
-
Homo sapiens
Pin1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function Pin1 is critical for the regulation of serine/threonine protein kinase B, PKB/Akt, stability and activation phosphorylation at S473 through the phosphorylated Thr-Pro motifs of Akt. Roles of Akt and Pin1 in oncogenesis, overview Homo sapiens