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Literature summary for 5.2.1.1 extracted from
- Computational investigations on the catalytic mechanism of maleate isomerase the role of the active site cysteine residues (2014), Phys. Chem. Chem. Phys., 16, 12462-12474 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Nocardia farcinica | Q5YXQ1 | - |
- |
| Nocardia farcinica IFM 10152 | Q5YXQ1 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | residue Cys194, upon activation via the substrate, acts as a nucleophile and Cys76 acts as an acid/base catalyst, forming a succinyl-Cys intermediate in a concerted fashion. The mechanism proceeds via multiple steps by substrate rotation around C2-C3 with the assistance of the now negatively charged Cys76, leading to the formation of fumarate | Nocardia farcinica | ? | - |
? |  |
| additional information | residue Cys194, upon activation via the substrate, acts as a nucleophile and Cys76 acts as an acid/base catalyst, forming a succinyl-Cys intermediate in a concerted fashion. The mechanism proceeds via multiple steps by substrate rotation around C2-C3 with the assistance of the now negatively charged Cys76, leading to the formation of fumarate | Nocardia farcinica IFM 10152 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MaiA | - |
Nocardia farcinica |
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Release 2023.1 (January 2023)
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