Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.1.99.6 extracted from

  • Niehaus, T.D.; Elbadawi-Sidhu, M.; Huang, L.; Prunetti, L.; Gregory, J.F.; de Crecy-Lagard, V.; Fiehn, O.; Hanson, A.D.
    Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function (2018), Biosci. Rep., 38, BSR20180223 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
K192A mutation decreases in vitro epimerase activity by more than 95% but does not affect dehydratase activity, reaction of EC 4.2.1.136. Mutant cells have essentially normal NAD(P)HX dehydratase activity and NAD(P)HX levels. Cells show metabolome changes, particularly in amino acids, which exceed those in cells lacking the entire yjeF gene. Mutant cells also have reduced levels of free (i.e. weakly bound or unbound) pyridoxal 5'-phosphate Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P31806 bifunctional NAD(P)H-hydrate repair enzyme Nnr, catalyzes both reactions of EC 5.1.99.6 and 4.2.1.136
-

Synonyms

Synonyms Comment Organism
NnR
-
Escherichia coli
YjeF
-
Escherichia coli