Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O09174 | - |
- |
Mus musculus C57BL/6 | O09174 | - |
- |
Source Tissue | Comment | Organism | Textmining |
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General Information | Comment | Organism |
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physiological function | knockout mouse models deficient in AMACR or MFE-2 (peroxisomal multifunctional enzyme type 2), in which this beta-oxidation pathway is prevented, display a residual C24-bile acid pool which, although greatly reduced, implies the existence of alternative pathways of bile acid synthesis. The total bile acid pool is decreased in Mfe-1-/- mice compared with wild-type and the levels of mature C24-bile acids are reduced in the double knockout mice when compared with AMACR-deficient mice | Mus musculus |