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Literature summary for 5.1.99.1 extracted from

  • Hamed, R.B.; Gomez-Castellanos, J.R.; Sean Froese, D.; Krysztofinska, E.; Yue, W.W.; Schofield, C.J.
    Use of methylmalonyl-CoA epimerase in enhancing crotonase stereoselectivity (2016), ChemBioChem, 17, 471-473 .
    View publication on PubMed

Application

Application Comment Organism
synthesis recombinant methylmalonyl-CoA epimerase enables biocatalytic epimerisation of C-2 methyl- and ethylmalonyl-CoA. When coupled with variant carboxymethylproline synthase CarB and crotonyl-CoA carboxylase reductase, the methylmalonyl-CoA epimerase forms part of a three-enzyme, one-pot procedure for the production of functionalised C-5 carboxyalkylprolines from crotonyl-CoA, carbon dioxide and L-glutamate semialdehyde/5-hydroxyproline/pyrroline-5-carboxylate Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96PE7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2R)-methylmalonyl-CoA
-
Homo sapiens (2S)-methylmalonyl-CoA
-
?
(2S)-ethylmalonyl-CoA
-
Homo sapiens (2R)-ethylmalonyl-CoA
-
?