Literature summary for 5.1.3.37 extracted from

Jerga, A.; Stanley, M.D.; Tipton, P.A.
Chemical mechanism and specificity of the C5-mannuronan epimerase reaction (2006), Biochemistry, 45, 9138-9144.

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Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
[mannuronan]-beta-D-mannuronate = [alginate]-alpha-L-guluronate	beta-elimination mechanism	Pseudomonas aeruginosa	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[mannuronan]-beta-D-mannuronate	-	Pseudomonas aeruginosa	[alginate]-alpha-L-guluronate	initial binding of the polymeric substrate to the enzyme is followed by a slow step that aligns the substrate more precisely for reaction. The substrate is moved into register with active site residues before catalysis took place. Release of the product also is slow	r

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Release 2023.1 (January 2023)