Literature summary for 5.1.3.2 extracted from

Park, J.; Tefsen, B.; Arentshorst, M.; Lagendijk, E.; van den Hondel, C.A.; van Die, I.; Ram, A.F.
Identification of the UDP-glucose-4-epimerase required for galactofuranose biosynthesis and galactose metabolism in A. niger (2014), Fungal Biol. Biotechnol., 1, 6 .

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Protein Variants

Protein Variants	Comment	Organism
additional information	targeted deletion of ugeA resulting in a severe reduction of galactofuranose in N-linked glucans	Aspergillus niger
N191D	naturally occuring mutation, the UgeA mutant shows reduced galactofuranose production, the mutant enzyme is partially active	Aspergillus niger

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell wall	-	Aspergillus niger	5618	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-glucose	Aspergillus niger	-	UDP-galactose	-	r
UDP-glucose	Aspergillus niger CBS 513.88 / FGSC A1513	-	UDP-galactose	-	r

Organism

Organism	UniProt	Comment	Textmining
Aspergillus niger	A2R3C7	-	-
Aspergillus niger CBS 513.88 / FGSC A1513	A2R3C7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-glucose	-	Aspergillus niger	UDP-galactose	-	r
UDP-glucose	-	Aspergillus niger CBS 513.88 / FGSC A1513	UDP-galactose	-	r

Synonyms

Synonyms	Comment	Organism
An14g03820	-	Aspergillus niger
UDP-glucose-4-epimerase	-	Aspergillus niger
UgeA	-	Aspergillus niger

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Aspergillus niger

General Information

General Information	Comment	Organism
evolution	presence of three putative UDP glucose-4-epimerases, UgeA, UgeB, and UgeC, in Aspergillus niger, encoded by genes An14g03820, An12g10410, and An02g11320. Enzyme UgeA belongs to the NAD(P)-dependent epimerase/dehydratase family	Aspergillus niger
malfunction	mutation of enzyme UgeA results in reduced galactofuranose production, deletion of gene ugeA abolishes the galactofuranose production	Aspergillus niger
physiological function	enzyme UgeA is required for the biosynthesis of galactofuranose as well as for galactose metabolism in Aspergillus niger. UgeA is required for growth on galactose in Aspergillus niger	Aspergillus niger

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Release 2023.1 (January 2023)