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Literature summary for 5.1.3.2 extracted from

  • Holden, H.M.; Rayment, I.; Thoden, J.B.
    Structure and function of enzymes of the Leloir pathway for galactose metabolism (2003), J. Biol. Chem., 278, 43885-43888.
    View publication on PubMed
Search for more literature for 5.1.3.2

Protein Variants

Protein Variants Comment Organism
Y299C mutation results in a loss of epimerase activity with regard to UDPgalactose by almost 5fold, it results in a gain of activity against UDP-GalNAc by more than 230fold Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens impairement of the enzyme results in galacosemia III that can lead to symptoms ranging from benign to severe ?
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information impairement of the enzyme results in galacosemia III that can lead to symptoms ranging from benign to severe Homo sapiens ?
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 ?
UDP-GlcNAc
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 Homo sapiens UDP-GalNAc
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 r
UDP-GlcNAc wild-type enzyme shows no interconversion of UDP-GlcNAc and UDP-GalNAc, mutation Y299C results in a gain of activity against UDP-GalNAc by more than 230fold Escherichia coli UDP-GalNAc
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 r