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Literature summary for 5.1.3.19 extracted from

  • Hannesson, H.H.; Hagner-McWhirter, A.; Tiedemann, K.; Lindahl, U.; Malmström, A.
    Biosynthesis of dermatan sulphate. Defructosylated Escherichia coli K4 capsular polysaccharide as a substrate for the D-glucuronyl C-5 epimerase, and an indication of a two-base reaction mechanism (1996), Biochem. J., 313, 589-596.
    View publication on PubMedView publication on EuropePMC
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.067
-
 D-glucuronosyl residues
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens most of the L-iduronic acid residues generated by the enzyme occur singly, although some formation of two or three consecutive L-iduronic acid residue containing disaccharide units is observed ?
-
 ?
additional information Homo sapiens epimerization of D-glucuronosyl residues to L-iduronosyl during biosynthesis of dermatan sulfate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Chondroitin D-glucuronate = dermatan L-iduronate two-base reaction mechanism, involving a monoprotic L-iso-specific base and a polyprotic D-gluco-specific base Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast skin Homo sapiens
-
fibroblast embryonic Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Chondroitin D-glucuronate capsular polysaccharide from Escherichia coli K4 consists of a chondroitin backbone to which beta-fructofuranose units are linked to C-3 of the D-glucuronic acid residues. Removal of the fructose units by mild acid hydrolysis provides a substrate for the chondroitin-glucuronate 5-epimerase Homo sapiens Dermatan L-iduronate
-
 ?
D-glucuronosyl residues
-
 Homo sapiens L-iduronosyl residues
-
 ?
additional information most of the L-iduronic acid residues generated by the enzyme occur singly, although some formation of two or three consecutive L-iduronic acid residue containing disaccharide units is observed Homo sapiens ?
-
 ?
additional information epimerization of D-glucuronosyl residues to L-iduronosyl during biosynthesis of dermatan sulfate Homo sapiens ?
-
 ?