Literature summary for 5.1.3.18 extracted from

Major, L.L.; Wolucka, B.A.; Naismith, J.H.
Structure and function of GDP-mannose-3',5'-epimerase: an enzyme which performs three chemical reactions at the same active site (2005), J. Am. Chem. Soc., 127, 18309-18320.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Arabidopsis thaliana

Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting drop vapor diffusion method, structures of complexes of the enzyme with GDP-alpha-D-mannose, GDP-beta-L-galactose and a mixture of GDP-beta-L-gulose. Structure of native wild-type enzyme in complex with GDP-D-mannose, native GME K178R, SeMet GME K178E, native GME Y174F in complex with GDP-L-galactose and native GME K217A in complex with GDP-D-mannose	Arabidopsis thaliana

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-alpha-D-mannose	-	Arabidopsis thaliana	GDP-beta-L-galactose + GDP-beta-L-gulose	-	?

Synonyms

Synonyms	Comment	Organism
GDP-mannose-3',5'-epimerase	-	Arabidopsis thaliana
GME	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)