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Literature summary for 5.1.3.17 extracted from

  • Rosenberg, E.; Prudnikova, T.; Zabarovsky, E.; Kashuba, V.; Grigorieva, E.
    D-Glucuronyl C5-epimerase cell type specifically affects angiogenesis pathway in different prostate cancer cells (2014), Tumor Biol., 35, 3237-3245 .
    View publication on PubMed
Search for more literature for 5.1.3.17

Application

Application Comment Organism
diagnostics GLCE upregulation plus expression pattern of a panel of six genes, discriminating morphologically different prostate cancer cell subtypes, is a potential marker of aggressive prostate cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
enzyme GLCE is ectopically re-expressed in morphologically different LNCaP and PC3 prostate cancer cells, quantitative real-time PCR enzyme expression analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O94923
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Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
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 Homo sapiens
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LNCaP cell
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 Homo sapiens
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additional information cDNA transcriptional microarray analysis of normal (PNT2) and prostate cancer (LNCaP, PC3, DU145) cells, overview Homo sapiens
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PC-3 cell
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 Homo sapiens
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PNT-2 cell
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 Homo sapiens
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prostate gland
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 Homo sapiens
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prostate gland cancer cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
D-glucuronyl C5-epimerase
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 Homo sapiens
Glce
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 Homo sapiens

General Information

General Information Comment Organism
evolution D-glucuronyl C5-epimerase activity and presence of L-iduronic acid seem to be intrinsic properties of cells from prokaryotes to humans Homo sapiens
physiological function D-glucuronyl C5-epimerase (GLCE) is one of the key heparan sulfate biosynthetic enzymes, responsible for the epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) in the heparan sulfate proteoglycans (HSPGs). IdoA presence increases a flexibility of HS chains and facilitates interaction of HSPGs with numerous extracellular and cell surface ligands including growth factors. The dynamic cooperation of proteoglycans, growth factor receptors, and integrins determines cell behavior, polarity, migration, differentiation, proliferation, and survival both in physiological and pathological conditions. D-glucuronyl C5-epimerase (GLCE) is involved in breast and lung carcinogenesis as a potential tumor suppressor gene, acting through inhibition of tumor angiogenesis and invasion/metastasis pathways. In prostate tumors, increased GLCE expression is associated with advanced disease, suggesting versatile effects of GLCE in different cancers, potential cancer-promoting effect of GLCE in prostate cancer and involvement of GLCE in carcinogenesis. GLCE up-regulation plus expression pattern of a panel of six genes, discriminating morphologically different prostate cancer cell sub-types, is suggested as a potential marker of aggressive prostate cancer Homo sapiens