Literature summary for 5.1.3.17 extracted from

Prudnikova, T.Y.; Soulitzis, N.; Kutsenko, O.S.; Mostovich, L.A.; Haraldson, K.; Ernberg, I.; Kashuba, V.I.; Spandidos, D.A.; Zabarovsky, E.R.; Grigorieva, E.V.
Heterogeneity of D-glucuronyl C5-epimerase expression and epigenetic regulation in prostate cancer (2013), Cancer Med., 2, 654-661.

Search for more literature for 5.1.3.17

Application

Application	Comment	Organism
medicine	the enzyme is a candidate molecular marker for advanced prostate cancer	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
DU-145 cell	-	Homo sapiens	-
LNCaP cell	-	Homo sapiens	-
additional information	quantitative RT-PCR enzyme expression analysis in benign and malign prostate tissues, overview	Homo sapiens	-
PC-3 cell	-	Homo sapiens	-
PNT-2 cell	-	Homo sapiens	-
prostate	decreased GLCE expression is observed in 10% of benign prostate hyperplasia tissues and 53% of prostate tumors, and increased GLCE mRNA levels are detected in 49% of benign prostate hyperplasia tissues and 21% of tumors, intratumoral heterogeneity of GLCE protein levels both in benign prostate hyperplasia and prostate cancer cells, resulting in a mixed population of GLCE-expressing and nonexpressing epithelial cells in vivo	Homo sapiens	-
prostate cancer cell	decreased GLCE expression is observed in 10% of benign prostate hyperplasia tissues and 53% of prostate tumors, and increased GLCE mRNA levels are detected in 49% of benign prostate hyperplasia tissues and 21% of tumors, intratumoral heterogeneity of GLCE protein levels both in benign prostate hyperplasia and prostate cancer cells, resulting in a mixed population of GLCE-expressing and nonexpressing epithelial cells in vivo	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
D-glucuronyl C5-epimerase	-	Homo sapiens
Glce	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	complex deregulation of GLCE expression in prostatic diseases compared with healthy prostate tissue	Homo sapiens
additional information	the enzyme may be used as a potential model to study the functional role of intratumor cell heterogeneity in prostate cancer progression	Homo sapiens
physiological function	heparansulfate proteoglycans play an important role in cell-cell and cell-matrix interactions and signaling, and one of the key enzymes in heparansulfate biosynthesis is D-glucuronyl C5-epimerase. The enzyme has a tumor suppressor function in breast and lung carcinogenesis	Homo sapiens

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Release 2023.1 (January 2023)