Cloned (Comment) | Organism |
---|---|
proteome expression analysis in wild-type and GNE-deficient embryonic stem cells, overview. GNE overexpression in HEK cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + H2O | Mus musculus | - |
UDP + N-acetylmannosamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic stem cell | cell proliferation is directly correlated with GNE-expression and the cellular sialic acid concentration. Growth-related genes are differentially expressed in GNE-deficient embryonic stem cells compared to wild-type embryonic stem cells | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | GNE is a bifunctional enzyme with UDP-GlcNAc 2-epimerase and ManNAc kinase activities | Mus musculus | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + H2O | - |
Mus musculus | UDP + N-acetylmannosamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GNE | - |
Mus musculus |
UDP-GlcNAc 2-epimerase | - |
Mus musculus |
UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | inactivation of GNE causes early embryonic lethality | Mus musculus |
metabolism | GNE catalyzes the first two steps of sialic acid biosynthesis in the cytosol | Mus musculus |
physiological function | GNE is required for sialic acid biosynthesis, the sialic acid pathway and the respective sialic acid precursors such as ManNAc do regulate the MAP kinase signalling pathway, influencing processes like cell proliferation, overview | Mus musculus |