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Literature summary for 5.1.3.14 extracted from

  • Weidemann, W.; Klukas, C.; Klein, A.; Simm, A.; Schreiber, F.; Horstkorte, R.
    Lessons from GNE-deficient embryonic stem cells: sialic acid biosynthesis is involved in proliferation and gene expression (2010), Glycobiology, 20, 107-117.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
proteome expression analysis in wild-type and GNE-deficient embryonic stem cells, overview. GNE overexpression in HEK cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + H2O Mus musculus
-
UDP + N-acetylmannosamine
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell cell proliferation is directly correlated with GNE-expression and the cellular sialic acid concentration. Growth-related genes are differentially expressed in GNE-deficient embryonic stem cells compared to wild-type embryonic stem cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GNE is a bifunctional enzyme with UDP-GlcNAc 2-epimerase and ManNAc kinase activities Mus musculus ?
-
?
UDP-N-acetyl-D-glucosamine + H2O
-
Mus musculus UDP + N-acetylmannosamine
-
?

Synonyms

Synonyms Comment Organism
GNE
-
Mus musculus
UDP-GlcNAc 2-epimerase
-
Mus musculus
UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

General Information

General Information Comment Organism
malfunction inactivation of GNE causes early embryonic lethality Mus musculus
metabolism GNE catalyzes the first two steps of sialic acid biosynthesis in the cytosol Mus musculus
physiological function GNE is required for sialic acid biosynthesis, the sialic acid pathway and the respective sialic acid precursors such as ManNAc do regulate the MAP kinase signalling pathway, influencing processes like cell proliferation, overview Mus musculus