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Literature summary for 5.1.3.14 extracted from

  • Amsili, S.; Zer, H.; Hinderlich, S.; Krause, S.; Becker-Cohen, M.; MacArthur, D.G.; North, K.N.; Mitrani-Rosenbaum, S.
    UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle? (2008), PLoS ONE, 3, e2477.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase interacts with the non-muscle form of alpha-actinin, alpha-actinin-1, in mature skeletal muscle cells. No significant difference in the binding of alpha-actinin-1 with either wild-type or mutant enzyme, and therefore no conclusions wether and how the interaction is relevant to the muscle-restricted pathology of hereditary inclusion body myopathy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
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Subunits

Subunits Comment Organism
More UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase interacts with the non-muscle form of alpha-actinin, alpha-actinin-1, in mature skeletal muscle cells Homo sapiens