Literature summary for 5.1.2.3 extracted from

Yang, S.Y.; Elzinga, M.
Association of both enoyl coenzyme A hydratase and 3-hydroxyacyl coenzyme A epimerase with an active site in the amino-terminal domain of the multifunctional fatty acid oxidation protein from Escherichia coli (1993), J. Biol. Chem., 268, 6588-6592.

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Protein Variants

Protein Variants	Comment	Organism
G116F	both the enoyl-CoA hydratase activity, EC 4.2.1.17 and the 3-hydroxyacyl-CoA epimerase activity, EC 5.1.2.3 are eliminated by the site-directed mutation alpha/Gly116 to Phe. This provides direct evidence that both enzymes are associated with a common active site on the amino-terminal domain of the multifunctional enzyme complex which exhibits the activities of EC 4.2.1.17, EC 2.3.1.16, EC 5.1.2.3, EC 1.1.1.35, and EC 5.3.3.3	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	wild type and mutant alpha/Gly116 to Phe	-

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Release 2023.1 (January 2023)