Literature summary for 5.1.2.2 extracted from

Meshach Paul, D.; Chadah, T.; Senthilkumar, B.; Sethumadhavan, R.; Rajasekaran, R.
Structural distortions due to missense mutations in human formylglycine-generating enzyme leading to multiple sulfatase deficiency (2017), J. Biomol. Struct. Dyn., 36, 3575-3585.

Search for more literature for 5.1.2.2

Application

Application	Comment	Organism
additional information	mandelate racemase from Pseudomonas putida is a promising candidate for the dynamic kinetic resolution of alpha-hydroxy carboxylic acids	Pseudomonas putida

Protein Variants

Protein Variants	Comment	Organism
additional information	evaluation of design of mandelate racemase with higher stability, usage of structural enzyme analysis for reengineering of mandelate racemase for enhanced thermal stability	Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-mandelate	Pseudomonas putida	-	(R)-mandelate	-	r

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas putida	P11444	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-mandelate	-	Pseudomonas putida	(R)-mandelate	-	r

Synonyms

Synonyms	Comment	Organism
mdlA	-	Pseudomonas putida

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
additional information	-	the thermal stability of mandelate racemase is investigated through molecular dynamics simulations in the temperature range of 30-90°C, structural alterations at increasing temperatures, overview. Radius of gyration, surface accessibility, and secondary structure content suggest the instability of mandelate racemase at high temperatures	Pseudomonas putida

General Information

General Information	Comment	Organism
additional information	the thermal stability of mandelate racemase is investigated through molecular dynamics simulations in the temperature range of 30-90°C	Pseudomonas putida

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Release 2023.1 (January 2023)