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Literature summary for 5.1.2.2 extracted from

  • Burley, R.K.; Bearne, S.L.
    Inhibition of mandelate racemase by the substrate-intermediate-product analogue 1,1-diphenyl-1-hydroxymethylphosphonate (2005), Bioorg. Med. Chem. Lett., 15, 4342-4344.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(R,S)-alpha-hydroxybenzylphosphonate
-
Pseudomonas putida
1,1-diphenyl-1-hydroxymethylphosphonate modest competitive inhibitor Pseudomonas putida

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.44
-
(R)-mandelate pH 7.5 Pseudomonas putida
0.95
-
(R)-mandelate pH 6.3 Pseudomonas putida
2.02
-
(R)-mandelate pH 8.7 Pseudomonas putida

Organism

Organism UniProt Comment Textmining
Pseudomonas putida
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-mandelate
-
Pseudomonas putida (S)-mandelate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0047
-
(R,S)-alpha-hydroxybenzylphosphonate
-
Pseudomonas putida
0.00591
-
1,1-diphenyl-1-hydroxymethylphosphonate pH 6.3 Pseudomonas putida
0.00693
-
1,1-diphenyl-1-hydroxymethylphosphonate pH 8.7 Pseudomonas putida
1.41
-
1,1-diphenyl-1-hydroxymethylphosphonate pH 7.5 Pseudomonas putida