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Literature summary for 5.1.1.3 extracted from

  • Sengupta, S.; Nagaraja, V.
    Inhibition of DNA gyrase activity by Mycobacterium smegmatis MurI (2008), FEMS Microbiol. Lett., 279, 40-47.
    View publication on PubMed
Search for more literature for 5.1.1.3

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in homologous expression system Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycolicibacterium smegmatis in addition to racemization activity, enzyme exhibits DNA gyrase activity by preventing DNA binding of gyrase. Sequestration of gyrase results in inhibition of all reactions catalyzed by DNA gyrase. Overexpression additiionally provides protection against ciprofloxacin ?
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 ?

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis
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-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3
-
 37°C Mycolicibacterium smegmatis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
 Mycolicibacterium smegmatis D-glutamate
-
 ?
additional information in addition to racemization activity, enzyme exhibits DNA gyrase activity by preventing DNA binding of gyrase. Sequestration of gyrase results in inhibition of all reactions catalyzed by DNA gyrase. Overexpression additiionally provides protection against ciprofloxacin Mycolicibacterium smegmatis ?
-
 ?
additional information in addition to racemization activity, enzyme exhibits DNA gyrase activity by preventing DNA binding of gyrase. Sequestration of gyrase results in inhibition of all reactions catalyzed by DNA gyrase. Overexpression additionally provides protection against ciprofloxacin Mycolicibacterium smegmatis ?
-
 ?