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Literature summary for 5.1.1.3 extracted from
- Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in gram-positive bacteria (2008), Bioorg. Med. Chem. Lett., 18, 6100-6103.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-(butylsulfanyl)-8-(4-fluorobenzyl)-4-(methylamino)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Staphylococcus aureus | Enterococcus faecalis |  |
| 2-(butylsulfanyl)-8-(4-fluorobenzyl)-4-(methylamino)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Enterococcus faecalis | Staphylococcus aureus | |
| 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine | comparison with effect on enzyme from Staphylococcus aureus | Enterococcus faecalis | |
| 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine | comparison with effect on enzyme from Enterococcus faecalis and Staphylococcus aureus | Enterococcus faecium | |
| 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine | comparison with effect on enzyme from Enterococcus faecalis | Staphylococcus aureus | |
| 4-amino-2-(butylsulfanyl)-8-(2,6-difluorobenzyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Staphylococcus aureus | Enterococcus faecalis | |
| 4-amino-2-(butylsulfanyl)-8-(2,6-difluorobenzyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Enterococcus faecalis | Staphylococcus aureus | |
| 4-amino-2-(butylsulfanyl)-8-(3,4-dichlorobenzyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Staphylococcus aureus | Enterococcus faecalis | |
| 4-amino-2-(butylsulfanyl)-8-(3,4-dichlorobenzyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Enterococcus faecalis | Staphylococcus aureus | |
| 4-amino-2-(butylsulfanyl)-8-(4-fluorobenzyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Staphylococcus aureus | Enterococcus faecalis | |
| 4-amino-2-(butylsulfanyl)-8-(4-fluorobenzyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Enterococcus faecalis | Staphylococcus aureus | |
| 4-amino-8-benzyl-2-(benzylsulfanyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Staphylococcus aureus | Enterococcus faecalis | |
| 4-amino-8-benzyl-2-(benzylsulfanyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Enterococcus faecalis | Staphylococcus aureus | |
| 4-amino-8-benzyl-2-(butylsulfanyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Staphylococcus aureus | Enterococcus faecalis | |
| 4-amino-8-benzyl-2-(butylsulfanyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Enterococcus faecalis | Staphylococcus aureus | |
| 4-amino-8-benzyl-2-(cyclopentylsulfanyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Staphylococcus aureus | Enterococcus faecalis | |
| 4-amino-8-benzyl-2-(cyclopentylsulfanyl)-5,8-dihydropteridine-6,7-dione | comparison with effect on enzyme from Enterococcus faecalis | Staphylococcus aureus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecalis | - |
- |
- |
| Enterococcus faecium | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00065 | - |
- |
Enterococcus faecalis | 4-amino-2-(butylsulfanyl)-8-(3,4-dichlorobenzyl)-5,8-dihydropteridine-6,7-dione | |
| 0.0009 | - |
- |
Enterococcus faecalis | 2-(butylsulfanyl)-8-(4-fluorobenzyl)-4-(methylamino)-5,8-dihydropteridine-6,7-dione | |
| 0.0011 | - |
- |
Staphylococcus aureus | 4-amino-2-(butylsulfanyl)-8-(4-fluorobenzyl)-5,8-dihydropteridine-6,7-dione | |
| 0.0015 | - |
- |
Enterococcus faecalis | 4-amino-2-(butylsulfanyl)-8-(2,6-difluorobenzyl)-5,8-dihydropteridine-6,7-dione | |
| 0.0015 | - |
- |
Staphylococcus aureus | 4-amino-2-(butylsulfanyl)-8-(3,4-dichlorobenzyl)-5,8-dihydropteridine-6,7-dione | |
| 0.0019 | - |
- |
Enterococcus faecalis | 4-amino-8-benzyl-2-(cyclopentylsulfanyl)-5,8-dihydropteridine-6,7-dione | |
| 0.0024 | - |
- |
Enterococcus faecalis | 4-amino-8-benzyl-2-(butylsulfanyl)-5,8-dihydropteridine-6,7-dione | |
| 0.0031 | - |
- |
Staphylococcus aureus | 4-amino-2-(butylsulfanyl)-8-(2,6-difluorobenzyl)-5,8-dihydropteridine-6,7-dione | |
| 0.0035 | - |
- |
Enterococcus faecalis | 4-amino-2-(butylsulfanyl)-8-(4-fluorobenzyl)-5,8-dihydropteridine-6,7-dione | |
| 0.0038 | - |
- |
Staphylococcus aureus | 2-(butylsulfanyl)-8-(4-fluorobenzyl)-4-(methylamino)-5,8-dihydropteridine-6,7-dione | |
| 0.0064 | - |
- |
Staphylococcus aureus | 4-amino-8-benzyl-2-(butylsulfanyl)-5,8-dihydropteridine-6,7-dione | |
| 0.007 | - |
- |
Enterococcus faecalis | 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine | |
| 0.0076 | - |
- |
Staphylococcus aureus | 4-amino-8-benzyl-2-(benzylsulfanyl)-5,8-dihydropteridine-6,7-dione | |
| 0.018 | - |
- |
Enterococcus faecium | 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine | |
| 0.021 | - |
- |
Enterococcus faecalis | 4-amino-8-benzyl-2-(benzylsulfanyl)-5,8-dihydropteridine-6,7-dione | |
| 0.052 | - |
- |
Staphylococcus aureus | 4-amino-8-benzyl-2-(cyclopentylsulfanyl)-5,8-dihydropteridine-6,7-dione | |
| 0.4 | - |
- |
Staphylococcus aureus | 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine | |
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