Inhibitors | Comment | Organism | Structure |
---|---|---|---|
malonate | - |
Homo sapiens | |
additional information | in silico and pharmacological inhibitor screenings, enzyme homology modeling, four active sites of hSR (two malonate-bound and two ligand-free forms) are used in this protein structure-based virtual screening, ligand docking | Homo sapiens | |
N-(4-bromophenyl)-N2-[(4-fluorophenoxy)acetyl]glycinamide | - |
Homo sapiens | |
N2-[(4-bromophenoxy)acetyl]-N-(2,6-difluorophenyl)glycinamide | - |
Homo sapiens | |
N2-[(4-bromophenoxy)acetyl]-N-(4-iodophenyl)glycinamide | - |
Homo sapiens | |
N2-[(4-fluorophenoxy)acetyl]-N-(4-iodophenyl)glycinamide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | Homo sapiens | - |
D-serine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9GZT4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | - |
Homo sapiens | D-serine | - |
r |
Synonyms | Comment | Organism |
---|---|---|
hSR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
1.31 | - |
pH and temperature not specified in the publication | Homo sapiens | malonate |
General Information | Comment | Organism |
---|---|---|
additional information | homology modeling of the ligand-free form of the human enzyme, in which the X-ray crystal structure of ligand-free rat enzyme, PDB ID 3HMK, is used as a template | Homo sapiens |