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Literature summary for 5.1.1.18 extracted from
- Serine racemase: an unconventional enzyme for an unconventional transmitter (2012), Amino Acids, 43, 1895-1904.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine | Mus musculus | - |
D-serine | - |
? |  |
| L-serine | Mus musculus C57BL/6 | - |
D-serine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Mus musculus C57BL/6 | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| cerebellum | adult, weak but significant enzyme signals are detected in GABAergic Purkinje cells | Mus musculus | - |
| cerebral cortex | - |
Mus musculus | - |
| corpus striatum | gamma-aminobutyric acid-ergic medium spiny neurons | Mus musculus | - |
| hippocampus | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| additional information | the enzyme colocalizes with neuron-specific nuclear protein, but not with astrocytic markers, namely, glial fibrillary acidic protein, and 3-phosphoglycerate dehydrogenase | Mus musculus | - |
| neuron | primarily, pyramidal neurons of the cerebral cortex and hippocampal CA1 region | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine | - |
Mus musculus | D-serine | - |
? | |
| L-serine | - |
Mus musculus C57BL/6 | D-serine | - |
? | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme KO mutant mice show reduced D-serine contents, reduced N-methyl-D-aspartate receptor activity, and impaired learning and memory abilities, altered morphological features of brain of SR-KO mice, altered behaviur and neurodegeneration in KO mice, phenotypes of three SR-KO mouse strains, overview. Enzyme expression in the liver is upregulated in nSR-KO_ITC mice | Mus musculus |
| physiological function | role of D-serine as an endogenous agonist of N-methyl-D-aspartate receptors (NMDARs). D-Serine is required for NMDAR activity during normal neurotransmission as well as NMDAR overactivation that takes place in neurodegenerative conditions | Mus musculus |
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Release 2023.1 (January 2023)
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