Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | competes with inhibitor phosphatidylinositol(4,5)-bisphosphate for enzyme binding | Mus musculus | |
metabotropic glutamate receptor | i.e. mGluR5, on glia, activation mechanism of the D-serine synthesis needed for NMDA neurotransmission, overview | Mus musculus | |
additional information | the glutamate transmission activates the enzyme by degrading phospholipids | Mus musculus |
Cloned (Comment) | Organism |
---|---|
HEK293 cells transfected with wild-type enzyme and metabotropic glutamate receptor display a 4fold increase in enzyme activity upon treatment with the metabotropic glutamate receptor agonist dihydroxyphenylglycine | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme mutants that cannot bind phosphatidylinositol(4,5)-bisphosphate lose their membrane localizations and display a 4fold enhancement of catalytic activity. Moreover, metabotropic glutamate receptors activation of the enzyme activity is abolished by inhibiting phospholipase C | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphatidylinositol-4,5-bisphosphate | i.e. PIP2, a physiological inhibitor of the enzyme, competes with activator ATP for enzyme binding. Activation of metabotropic glutamate receptors on glia leads to phospholipase C-mediated degradation of PIP2, relieving SR inhibition | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | membrane association via phospholipid binding. The enzyme is prominently associated with the plasma membrane but also is detected in granular structures that may be vesicles associated with the plasma membrane or other cellular components | Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | Mus musculus | D-serine is stored primarily within astrocytes ensheathing neuronal synapses containing NMDA receptors, model of D-serine signalling in the brain, overview | D-serine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Mus musculus | - |
brain | - |
Mus musculus | - |
glia | - |
Mus musculus | - |
neuron | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | - |
Mus musculus | D-serine | - |
? | |
L-serine | D-serine is stored primarily within astrocytes ensheathing neuronal synapses containing NMDA receptors, model of D-serine signalling in the brain, overview | Mus musculus | D-serine | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.013 | - |
- |
Mus musculus | phosphatidylinositol-4,5-bisphosphate |