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Literature summary for 5.1.1.18 extracted from
- Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor (2009), J. Med. Chem., 52, 6032-6041.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus |  |
| DTT | - |
Mus musculus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| enzyme expression in Escherichia coli strain MC1061 | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Acetohydroxamic acid | i.e. Lithostat | Mus musculus | |
| adipodihydroxamic acid | - |
Mus musculus | |
| DL-Serine hydroxamate | - |
Mus musculus | |
| DL-Threonine hydroxamate | - |
Mus musculus | |
| glutarodihydroxamic acid | - |
Mus musculus | |
| glycine | - |
Mus musculus | |
| Glycine hydroxamate | - |
Mus musculus | |
| L-aspartic acid | - |
Mus musculus | |
| L-aspartic acid beta-hydroxamate | a competitive and selective serine racemase inhibitor | Mus musculus | |
| malonodihydroxamic acid | - |
Mus musculus | |
| additional information | small aliphatic hydroxamic acids as potent serine racemase inhibitors, interaction with the pyridoxal-5'-phosphate cofactor, mechanistic analysis, overview. Some of these hydroxamic acids can act as nonspecific inhibitors of pyridoxal 5'-phosphate-dependent enzymes, the nonspecific effect is likely due to irreversible interaction of the hydroxamic acid moiety with pyridoxal 5'-phosphate to form aldoxime species | Mus musculus | |
| oxalodihydroxamic acid | - |
Mus musculus | |
| suberodihydroxamic acid | - |
Mus musculus | |
| succinodihydroxamic acid | - |
Mus musculus | |
| vorinostat | i.e. Zolinza | Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | activates, but is not involved in enzyme inhibition by hydroxamic acids | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine | Mus musculus | - |
D-serine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme from Escherichia coli strain MC1061 by hydrophobic interaction and anion exchange chromatography, followed by ATP affinity chromatography and dialysis | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine | - |
Mus musculus | D-serine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SRR | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | dependent on | Mus musculus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.3 | - |
L-aspartic acid beta-hydroxamate | pH 8.0 | Mus musculus | |
| 1.64 | - |
glycine | pH 8.0 | Mus musculus | |
| 1.9 | - |
L-aspartic acid | pH 8.0 | Mus musculus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is responsible for the biosynthesis of the neurotransmitter D-serine, which activates N-methyl-D-aspartate receptors in the central nervous system | Mus musculus |
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Release 2023.1 (January 2023)
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