Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of mice with an ENU-induced mutation, SrrY269stop, that results in a complete loss of Srr activity and dramatically reduced D-serine levels. Mutant mice display behaviors relevant to schizophrenia, including impairments in prepulse inhibition, sociability and spatial discrimination. Behavioral deficits are exacerbated by an NMDAR antagonist and ameliorated by D-serine or the atypical antipsychotic clozapine. Expression profiling reveals that the Srr mutation influences several genes that are linked to schizophrenia and cognitive ability, expression pattern of the enzyme in mutant brain tissues, detailed phenotype, overview | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29000 | - |
x * 29000, truncated mutant enzyme, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | Mus musculus | - |
D-serine | D-serine is an important modulator of the N-methyl-D-aspartate receptor function | ? | |
L-serine | Homo sapiens | - |
D-serine | D-serine is an important modulator of the N-methyl-D-aspartate receptor function | ? | |
L-serine | Mus musculus C57BL/6JJcl | - |
D-serine | D-serine is an important modulator of the N-methyl-D-aspartate receptor function | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
different SRR genetic variants | - |
Mus musculus | - |
and strain DBA/2JJcl | - |
Mus musculus C57BL/6JJcl | - |
and strain DBA/2JJcl | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | expression pattern of the enzyme in brain tissues | Mus musculus | - |
cerebellum | - |
Mus musculus | - |
frontal cortex | - |
Mus musculus | - |
frontal lobe | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | - |
Mus musculus | D-serine | - |
? | |
L-serine | - |
Homo sapiens | D-serine | - |
? | |
L-serine | - |
Mus musculus | D-serine | D-serine is an important modulator of the N-methyl-D-aspartate receptor function | ? | |
L-serine | - |
Homo sapiens | D-serine | D-serine is an important modulator of the N-methyl-D-aspartate receptor function | ? | |
L-serine | - |
Mus musculus C57BL/6JJcl | D-serine | - |
? | |
L-serine | - |
Mus musculus C57BL/6JJcl | D-serine | D-serine is an important modulator of the N-methyl-D-aspartate receptor function | ? |
Subunits | Comment | Organism |
---|---|---|
? | x * 29000, truncated mutant enzyme, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
SRR | - |
Mus musculus |
SRR | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | serine racemase is associated with schizophrenia susceptibility in a mouse model, abnormal N-methyl-D-aspartate receptor function is implicated in the pathophysiology of schizophrenia | Mus musculus |
malfunction | serine racemase is associated with schizophrenia susceptibility in humans, abnormal N-methyl-D-aspartate receptor function is implicated in the pathophysiology of schizophrenia | Homo sapiens |