Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the amyloid beta-peptide and secreted forms, liberated by alpha- or beta-secretase, of beta-amyloid precursor protein induce enzyme expression and lead to elevated D-serine levels in microglia, overview | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
cloning from genomic DNA, DNA and amino acid sequence determination | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | Rattus norvegicus | - |
D-serine | - |
? | |
L-serine | Homo sapiens | - |
D-serine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9GZT4 | - |
- |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocytoma cell | - |
Homo sapiens | - |
HAP1 cell | a microglial cell line | Rattus norvegicus | - |
microglia | primary from neonatal rats, mixed glial cultures | Rattus norvegicus | - |
T-98G cell | an astrocytoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | - |
Rattus norvegicus | D-serine | - |
? | |
L-serine | - |
Homo sapiens | D-serine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SRace | - |
Rattus norvegicus |
SRace | - |
Homo sapiens |