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Literature summary for 5.1.1.18 extracted from

  • Cook, S.P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I.
    Direct calcium binding results in activation of brain serine racemase (2002), J. Biol. Chem., 277, 27782-27792.
    View publication on PubMed
Search for more literature for 5.1.1.18

Inhibitors

Inhibitors Comment Organism Structure
cystamine 50% inhibition at 0.0081 mM Mus musculus
L-Cycloserine 10 mM, 45% inhibition Mus musculus
L-cysteine 10 mM, 90% inhibition Mus musculus
L-serine-O-sulfate 10 mM, 50% inhibition Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.8
-
 L-serine pH 8.1, 37°C Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ or Mn2+, required, binding konstant 0.0062 mM. Possible glutamatergic-mediated regulation of enzyme via intracellular calcium concentration Mus musculus
EDTA complete inhibition, provokes a profound conformational change Mus musculus
Mn2+ or Ca2+, required Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37500
-
 2 * 37500, SDS-PAGE, dimer-tetramer equilibrium Mus musculus
37500
-
 4 * 37500, SDS-PAGE, dimer-tetramer equilibrium Mus musculus
82900
-
 gel filtration Mus musculus
153000
-
 gel filtration Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
-
 Mus musculus D-serine
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 37500, SDS-PAGE, dimer-tetramer equilibrium Mus musculus
tetramer 4 * 37500, SDS-PAGE, dimer-tetramer equilibrium Mus musculus