Literature summary for 5.1.1.17 extracted from

Ullan, R.V.; Casqueiro, J.; Banuelos, O.; Fernandez, F.J.; Gutierrez, S.; Martin, J.F.
A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum (2002), J. Biol. Chem., 277, 46216-46225.

Search for more literature for 5.1.1.17

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
isopenicillin N	Amycolatopsis lactamdurans	part of the cephalosporin pathway	penicillin N	-	?
isopenicillin N	Acremonium chrysogenum	part of the cephalosporin pathway	penicillin N	-	?
isopenicillin N	Acremonium chrysogenum C10 / ATCC 48272	part of the cephalosporin pathway	penicillin N	-	?

Organism

Organism	UniProt	Comment	Textmining
Acremonium chrysogenum	-	-	-
Amycolatopsis lactamdurans	-	also known as Amycolatopsis lactamdurans, cefD1 and cefD2 gene products are involved in epimerization of isopenicillin N into penicillin N	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	92.0 units, 1 unit is the activity forming 1 ng of cephalosporin/min in a coupled assay, activity in cell extract	Acremonium chrysogenum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
isopenicillin	-	Amycolatopsis lactamdurans	penicillin N	-	?
isopenicillin	-	Acremonium chrysogenum	penicillin N	-	?
isopenicillin	-	Acremonium chrysogenum C10 / ATCC 48272	penicillin N	-	?
isopenicillin N	part of the cephalosporin pathway	Amycolatopsis lactamdurans	penicillin N	-	?
isopenicillin N	part of the cephalosporin pathway	Acremonium chrysogenum	penicillin N	-	?
isopenicillin N	part of the cephalosporin pathway	Acremonium chrysogenum C10 / ATCC 48272	penicillin N	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)