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Literature summary for 5.1.1.13 extracted from
- D-Amino acid metabolism in mammals: biosynthesis, degradation and analytical aspects of the metabolic study (2011), J. Chromatogr. B, 879, 3162-3168.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45500 | - |
x * 45500 | Mus musculus |
| 45500 | - |
x * 45500 | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-aspartate | Mus musculus | - |
D-aspartate | - |
? |  |
| L-aspartate | Rattus norvegicus | - |
D-aspartate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | moderate expression level | Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
| brain | high expression level, D-aspartate is abundant in the embryonic brain, but drastically decreases during postnatal development. The enzyme is located in the paraventricular and supraoptic nuclei, the cerebral cortex, the hippocampus, the dentate gyrus, the pineal gland, and the posterior pituitary gland | Mus musculus | - |
| cerebral cortex | - |
Mus musculus | - |
| dentate gyrus | - |
Mus musculus | - |
| heart | high expression level | Mus musculus | - |
| hippocampus | - |
Mus musculus | - |
| kidney | low activity | Mus musculus | - |
| kidney | low activity | Rattus norvegicus | - |
| liver | low activity | Mus musculus | - |
| liver | low activity | Rattus norvegicus | - |
| additional information | highest aspartate racemase activity is observed in tissues where D-aspartate is present at high concentrations | Mus musculus | - |
| additional information | highest aspartate racemase activity is observed in tissues where D-aspartate is present at high concentrations | Rattus norvegicus | - |
| paraventricular nucleus | - |
Mus musculus | - |
| pineal gland | - |
Mus musculus | - |
| pituitary gland | high activity | Mus musculus | - |
| pituitary gland | high activity | Rattus norvegicus | - |
| supraoptic nucleus | - |
Mus musculus | - |
| testis | - |
Rattus norvegicus | - |
| testis | high expression level | Mus musculus | - |
| thyroid | - |
Mus musculus | - |
| thyroid | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-aspartate | - |
Mus musculus | D-aspartate | - |
? | |
| L-aspartate | - |
Rattus norvegicus | D-aspartate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 45500 | Mus musculus |
| ? | x * 45500 | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | dependent on | Mus musculus | |
| pyridoxal 5'-phosphate | dependent on | Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | retrovirus-mediated expression of short-hairpin RNA complementary to aspartate racemase in newborn neurons of the hippocampus results in a defect in dendritic development and impaired survival of the newborn neurons | Mus musculus |
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Release 2023.1 (January 2023)
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