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Literature summary for 5.1.1.11 extracted from

  • Stachelhaus, T.; Walsh, C.T.
    Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase (2000), Biochemistry, 39, 5775-5787.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli as a C-terminal His tag fusion Brevibacillus brevis

Protein Variants

Protein Variants Comment Organism
D767S mutant enzyme is impaired in approach to D-Phe/L-Phe-S-4'phosphopantetheine equilibrium only for D-Phe to L-Phe direction Brevibacillus brevis
E892A mutant enzyme is dramatically impaired in approach to D-Phe/L-Phe-S-4'phosphopantetheine equilibrium from either D-Phe or L-Phe Brevibacillus brevis
E892A only slightly active with L-Phe, unimpaired reaction with D-Phe Brevibacillus brevis
H753A only slightly active with L-Phe, unimpaired reaction with D-Phe Brevibacillus brevis
R896A mutant enzyme is dramatically impaired in approach to D-Phe/L-Phe-S-4'phosphopantetheine equilibrium from either D-Phe or L-Phe Brevibacillus brevis

Organism

Organism UniProt Comment Textmining
Brevibacillus brevis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Brevibacillus brevis

Synonyms

Synonyms Comment Organism
PheATE
-
Brevibacillus brevis