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Literature summary for 5.1.1.1 extracted from

  • Faraci, W.S.; Walsh, C.T.
    Mechanism of inactivation of alanine racemase by beta,beta,beta-trifluoroalanine (1989), Biochemistry, 28, 431-437.
    View publication on PubMed
Search for more literature for 5.1.1.1

Inhibitors

Inhibitors Comment Organism Structure
beta,beta,beta-trifluoroalanine nucleophilic attack of Lys38 on the electrophilic beta-difluoro-alpha,beta-unsaturated imine Geobacillus stearothermophilus
beta,beta,beta-trifluoroalanine nucleophilic attack of Lys38 on the electrophilic beta-difluoro-alpha,beta-unsaturated imine Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Ala Salmonella enterica subsp. enterica serovar Typhimurium enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall ?
-
 ?
L-Ala Geobacillus stearothermophilus enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall ?
-
 ?

Organism

Organism UniProt Comment Textmining
Geobacillus stearothermophilus
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala
-
 Salmonella enterica subsp. enterica serovar Typhimurium D-Ala
-
 ?
L-Ala
-
 Geobacillus stearothermophilus D-Ala
-
 ?
L-Ala enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
L-Ala enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall Geobacillus stearothermophilus ?
-
 ?