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Literature summary for 5.1.1.1 extracted from
- Biosynthetic alanine racemase of Salmonella typhimurium: purification and characterization of the enzyme encoded by the alr gene (1986), Biochemistry, 25, 3261-3267.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-beta-fluoroalanine | - |
Salmonella enterica subsp. enterica serovar Typhimurium |  |
| D-Chloroalanine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| D-O-acetylserine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| L-beta-chloroalanine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| L-chloroalanine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2 | - |
D-Ala | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 2.7 | - |
L-Ala | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 42000 | - |
1 * 42000, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
| 43000 | - |
gel filtration | Salmonella enterica subsp. enterica serovar Typhimurium |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
overproducing strain | - |
| Salmonella enterica subsp. enterica serovar Typhimurium overproducing | - |
overproducing strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| alr gene encoded | Salmonella enterica subsp. enterica serovar Typhimurium |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 22 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Ala | - |
Salmonella enterica subsp. enterica serovar Typhimurium | D-Ala | - |
? | |
| L-Ala | - |
Salmonella enterica subsp. enterica serovar Typhimurium overproducing | D-Ala | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 42000, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | the sequence of 10 amino acid residues around the Lys residue, to which pyridoxal 5'-phosphate is bound, is identical with that of the dadB racemase | Salmonella enterica subsp. enterica serovar Typhimurium | |
| pyridoxal 5'-phosphate | Km: 0.000033 mM | Salmonella enterica subsp. enterica serovar Typhimurium | |
| pyridoxal 5'-phosphate | contains one mol of pyridoxal 5'-phosphate per mol of enzyme | Salmonella enterica subsp. enterica serovar Typhimurium | |
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