Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.99.1.9 extracted from

  • Dailey, H.A.; Gerdes, S.; Dailey, T.A.; Burch, J.S.; Phillips, J.D.
    Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin (2015), Proc. Natl. Acad. Sci. USA, 112, 2210-2215.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.99.1.9

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0018
-
 coproporphyrin III pH 7.5, 37°C Bacillus subtilis
0.0105
-
 coproporphyrin III pH 7.5, 37°C Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrin III + Fe2+ Bacillus subtilis
-
 Fe-coproporphyrin III + 2 H+
-
 ?
coproporphyrin III + Fe2+ Mycobacterium tuberculosis
-
 Fe-coproporphyrin III + 2 H+
-
 ?
coproporphyrin III + Fe2+ Cutibacterium acnes
-
 Fe-coproporphyrin III + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Cutibacterium acnes
-
-
-
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrin III + Co2+ specific activity with Co2+ is 2.8fold higher than with Fe2+ Mycobacterium tuberculosis Co-coproporphyrin III + 2 H+
-
 ?
coproporphyrin III + Co2+ specific activity with Co2+ is 6fold higher than with Fe2+ Bacillus subtilis Co-coproporphyrin III + 2 H+
-
 ?
coproporphyrin III + Cu2+ specific activity with Cu2+ is 4.15old higher than with Fe2+ Bacillus subtilis Cu-coproporphyrin III + 2 H+
-
 ?
coproporphyrin III + Cu2+ specific activity with Cu2+ is 5.35old higher than with Fe2+ Mycobacterium tuberculosis Cu-coproporphyrin III + 2 H+
-
 ?
coproporphyrin III + Fe2+
-
 Bacillus subtilis Fe-coproporphyrin III + 2 H+
-
 ?
coproporphyrin III + Fe2+
-
 Mycobacterium tuberculosis Fe-coproporphyrin III + 2 H+
-
 ?
coproporphyrin III + Fe2+
-
 Cutibacterium acnes Fe-coproporphyrin III + 2 H+
-
 ?
coproporphyrin III + Ni2+ specific activity with Ni2+ is 4fold lower than with Fe2+ Bacillus subtilis Ni-coproporphyrin III + 2 H+
-
 ?
coproporphyrin III + Ni2+ specific activity with Ni2+ is 80% compared to activity with Fe2+ Mycobacterium tuberculosis Ni-coproporphyrin III + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
hemH
-
 Bacillus subtilis
hemH
-
 Mycobacterium tuberculosis
hemH gene name. HemH and HemQ exist as a fusion protein Cutibacterium acnes

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0078
-
 coproporphyrin III pH 7.5, 37°C Bacillus subtilis
0.03
-
 coproporphyrin III pH 7.5, 37°C Mycobacterium tuberculosis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.9
-
 coproporphyrin III pH 7.5, 37°C Mycobacterium tuberculosis
4.3
-
 coproporphyrin III pH 7.5, 37°C Bacillus subtilis