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Literature summary for 4.99.1.8 extracted from

  • Kapishnikov, S.; Grolimund, D.; Schneider, G.; Pereiro, E.; McNally, J.; Als-Nielsen, J.; Leiserowitz, L.
    Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography (2017), Sci. Rep., 7, 7610 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
analysis development of a high resolution correlative combination of cryo soft X-ray tomography to obtain 3D parasite ultrastructure with cryo X-ray fluorescence microscopy to measure heme concentrations Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
vacuole
-
Plasmodium falciparum 5773
-

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q8IL04
-
-

General Information

General Information Comment Organism
physiological function non-crystalline heme is stored within hemoglobin in the digestive vacuole, and then converted to crystallized heme with the assistance of the heme detoxification protein. A coupling exists between the rate of hemoglobin digestion and the rate of heme dimerization and crystallization. In vivo heme crystallization occurs at a rate of about 1000/s, which is close to the in vitro rate of heme dimerization measured for the heme detoxification protein (HDP). HDP may be primarily responsible for heme crystallization Plasmodium falciparum