Literature summary for 4.99.1.8 extracted from

Gupta, P.; Mehrotra, S.; Sharma, A.; Chugh, M.; Pandey, R.; Kaushik, A.; Khurana, S.; Srivastava, N.; Srivastava, T.; Deshmukh, A.; Panda, A.; Aggarwal, P.; Bhavesh, N.S.; Bhatnagar, R.K.; Mohmmed, A.; Gupta, D.; Malhotra, P.
Exploring heme and hemoglobin binding regions of Plasmodium heme detoxification protein for new antimalarial discovery (2017), J. Med. Chem., 60, 8298-8308 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-[2-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-pyridinyl]-3,4-dihydro-2H-1,5-benzodioxepine-7-carboxamide	compound binds the modeled HDP structure in the heme/hemoglobin-binding pockets, and inhibits parasite growth in a dose-dependent manner	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	Q8IL04	-	-

General Information

General Information	Comment	Organism
physiological function	identification of two heme binding sites and a hemoglobin binding site in Pf HDP. Treatment of Plasmodium falciparum 3D7 parasites with peptide corresponding to the hemoglobin binding domain results in food vacuole abnormalities similar to that seen with cysteine protease inhibitor, E-64	Plasmodium falciparum

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Release 2023.1 (January 2023)