Literature summary for 4.99.1.8 extracted from

Slater, A.F.G.; Swiggard, W.J.; Orton, B.R.; Flitter, W.D.; Goldberg, D.E.; Cerami, A.; Henderson, G.B.
An iron-carboxylate bond links the heme units of malaria pigment (1991), Proc. Natl. Acad. Sci. USA, 88, 325-329.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ferriprotoporphyrin IX	Plasmodium falciparum	hemozoin consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another. The hemes are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme	beta-hematin	-	?

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ferriprotoporphyrin IX	hemozoin consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another. The hemes are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme	Plasmodium falciparum	beta-hematin	-	?
ferriprotoporphyrin IX	hemozoin consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another	Plasmodium falciparum	beta-hematin	-	?

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Release 2023.1 (January 2023)