BRENDA - Enzyme Database show
show all sequences of 4.99.1.8

An iron-carboxylate bond links the heme units of malaria pigment

Slater, A.F.G.; Swiggard, W.J.; Orton, B.R.; Flitter, W.D.; Goldberg, D.E.; Cerami, A.; Henderson, G.B.; Proc. Natl. Acad. Sci. USA 88, 325-329 (1991)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ferriprotoporphyrin IX
Plasmodium falciparum
hemozoin consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another. The hemes are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme
beta-hematin
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Plasmodium falciparum
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ferriprotoporphyrin IX
hemozoin consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another. The hemes are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme
694922
Plasmodium falciparum
beta-hematin
-
-
-
?
ferriprotoporphyrin IX
hemozoin consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another
694922
Plasmodium falciparum
beta-hematin
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ferriprotoporphyrin IX
Plasmodium falciparum
hemozoin consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another. The hemes are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme
beta-hematin
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ferriprotoporphyrin IX
hemozoin consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another. The hemes are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme
694922
Plasmodium falciparum
beta-hematin
-
-
-
?
ferriprotoporphyrin IX
hemozoin consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another
694922
Plasmodium falciparum
beta-hematin
-
-
-
?
Other publictions for EC 4.99.1.8
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
748370
Gupta
Exploring heme and hemoglobin ...
Plasmodium falciparum
J. Med. Chem.
60
8298-8308
2017
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1
1
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749357
Kapishnikov
Unraveling heme detoxificatio ...
Plasmodium falciparum
Sci. Rep.
7
7610
2017
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1
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1
1
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747897
Soni
Cloning, expression and funct ...
Plasmodium vinckei petteri
Gene
566
109-119
2015
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1
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4
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1
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7
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1
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1
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1
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1
1
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730953
Nakatani
Identification of essential hi ...
Plasmodium falciparum
Sci. Rep.
4
6137
2014
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1
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10
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2
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1
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1
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1
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10
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1
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1
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729137
Nakatani
Heme-binding properties of hem ...
Plasmodium falciparum
Biochem. Biophys. Res. Commun.
439
477-480
2013
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1
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1
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2
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1
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1
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1
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1
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1
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1
1
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1
1
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730826
Chugh
Protein complex directs hemogl ...
Plasmodium falciparum
Proc. Natl. Acad. Sci. USA
110
5392-5397
2013
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1
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1
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2
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3
1
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1
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3
1
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730307
Kattenberg
New developments in malaria di ...
Plasmodium falciparum, Plasmodium falciparum NF54
mAbs
4
120-126
2012
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6
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2
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714676
Wagner
Hemozoin: malaria's built-in a ...
Plasmodium falciparum
Cell Host Microbe
7
5-6
2010
-
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-
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1
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1
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1
1
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716125
Shio
Innate inflammatory response t ...
Plasmodium falciparum
Microbes Infect.
12
889-899
2010
-
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1
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1
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1
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1
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692596
Vinayak
Limited genetic variation in t ...
Plasmodium falciparum
Infect. Genet. Evol.
9
286-289
2009
-
1
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2
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694830
Jani
HDP - a novel heme detoxificat ...
Plasmodium falciparum, Plasmodium yoelii
PLos Pathog.
25
0000
2008
-
2
2
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1
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2
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4
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1
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2
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1
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694922
Slater
An iron-carboxylate bond links ...
Plasmodium falciparum
Proc. Natl. Acad. Sci. USA
88
325-329
1991
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