Literature summary for 4.98.1.1 extracted from

Wu, J.; Wen, S.; Zhou, Y.; Chao, H.; Shen, Y.
Human ferrochelatase insights for the mechanism of ferrous iron approaching protoporphyrin IX by QM/MM and QTCP free energy studies (2016), J. Chem. Inf. Model., 56, 2421-2433 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
quantum mechanical/molecular mechanics studies. The ferrous iron probably coordinates with residue Met76 at the binding site, and His263 plays the role of proton acceptor. The rate-determining step is either the first proton removed by His263 or the proton transition within the porphyrin with an energy barrier of 14.99 or 14.87 kcal/mol, respectively	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P22830	-	-

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Release 2023.1 (January 2023)