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Literature summary for 4.98.1.1 extracted from

  • Asuru, A.P.; An, M.; Busenlehner, L.S.
    Dissection of porphyrin-induced conformational dynamics in the heme biosynthesis enzyme ferrochelatase (2012), Biochemistry, 51, 7116-7127.
    View publication on PubMed
Search for more literature for 4.98.1.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli HB101 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
 Homo sapiens 5743
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ contains 1.8 mol iron per mol ferrochelatase Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
84000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoporphyrin IX + Fe2+ Homo sapiens
-
 protoheme IX + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mesoporphyrin IX + Fe2+
-
 Homo sapiens ?
-
 ?
protoporphyrin IX + Fe2+
-
 Homo sapiens protoheme IX + 2 H+
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
[2Fe-2S]-center
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the insertion ferrous iron into protoporphyrin IX as the last step in heme biosynthesis Homo sapiens